Episode 65 - Alessandra Zonari - OneSkin & the OS-01 Peptide: Strengthen Your Skin at the Cellular Level

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Meet Alessandra Zonari

Alessandra Zonari, PhD, OneSkin Co-Founder & CSO, is a leading expert in stem cell biology and skin regeneration, driven by a personal mission to transform the way we age. Her journey began in Brazil, where she witnessed the impact of age-related diseases on her family, inspiring her to explore the connection between cellular health and longevity. As co-founder and CSO of OneSkin, Alessandra develops groundbreaking skin care products that target cellular senescence, one of the key hallmarks of skin aging.


What We Talk About

• Dr. Alessandra Zonari’s background in stem cell research and how it led to co-founding OneSkin with three fellow PhD scientists from Brazil.
• How the OS-1 peptide works by targeting senescent cells and reducing skin inflammation to rebuild collagen and strengthen the skin barrier.
• The rigorous R&D process behind OneSkin, including lab-grown skin testing, peptide screening, and clinical trials.
• Why inflammation is a root cause of skin aging and how OS-1 helps build resilience from within.
• When visible aging starts in the skin, and why your 30s are a critical window to start proactive care.
• How OneSkin compares to traditional anti-aging ingredients like retinol and why it’s safe for sensitive skin.
• A breakdown of their product line, from body and face moisturizers to eye cream, tinted SPF, hair serum, and lip treatment.
• The science behind exosomes and stem cells in skincare, and why peptides offer a more stable and effective alternative.
• How OneSkin is leading the shift from cosmetic beauty to skin health and longevity through ongoing research and innovation.


Episode Resources

Learn More About One Skin
Topical skincare powered by senotherapeutics to target skin aging at the molecular level and extend skin healthspan.

Visit oneskin.co/TRAILTOHEALTH and use code TRAILTOHEALTH for 15% off your first purchase.



Keywords

OneSkin, OS-1 peptide, senescent cells, skin aging, skin barrier, collagen production, inflammation, peptides vs retinol, scalp serum, lip SPF, anti-aging skincare, Alessandra Zonari, lab-grown skin.