Episode 79 - Shalin Shah - Why Testosterone Decline Is the New Health Epidemic

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Meet Shalin Shah

Shalin Shah is the CEO of Marius Pharmaceuticals and a leader in metabolic and men’s health. He spearheaded the FDA approval of the first oral testosterone therapy for men with low testosterone. With a mission to make hormone health more accessible, Shalin advocates for education, innovation, and redefining testosterone therapy as a foundation for longevity and quality of life.


What We Talk About

• Why testosterone levels are rapidly declining in both men and women.
• The connection between low testosterone, obesity, and chronic metabolic disease.
• How environmental toxins, plastics, and fragrances disrupt hormones.
• The symptoms and early warning signs of testosterone deficiency.
• Why younger men are now showing record-low testosterone levels.
• What to test for: total vs. free testosterone, SHBG, LH, FSH, and estradiol.
• The problem with “normal” lab ranges and how they’ve shifted over time.
• Comparing injections, gels, pellets, and oral testosterone therapy.
• Why oral testosterone is changing the future of hormone replacement.
• The safety differences between delivery methods and how to minimize side effects.
• Myths about testosterone and heart disease, cardiovascular risk, and prostate cancer.
• How testosterone impacts mood, energy, metabolism, and longevity.
• The fertility question: how TRT affects sperm count and new studies addressing it.
• Why testing testosterone should be part of standard preventive care.
• The future of hormone optimization for women and the FDA’s changing approach.


Episode Resources

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Pulsetto|
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Earthing
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Higher Dose
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Keywords

Testosterone, Hormone Health, TRT, Metabolic Health, Longevity, Low Testosterone, Hormone Optimization, Endocrine Disruptors, Fertility, Men’s Health, Women’s Health, Energy, Libido, Aging, Mitochondria, Cellular Health, FDA Approval, Hormone Testing, Preventive Medicine