Episode 71 - Dr. Joanne Kennedy - Unpacking Histamine & Methylation

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Meet Dr. Joanne Kennedy

Joanne Kennedy is a naturopath specializing in histamine intolerance, MTHFR, and methylation, based in Sydney, Australia. She runs a successful clinical practice and consults with patients globally, focusing on identifying the root causes of illness through functional pathology testing and personalized assessments, including genetic testing when needed. Joanne is the host of The Histamine Well podcast, exploring topics related to histamine, methylation, and holistic health. She also created The Histamine & Methylation Online Group Coaching Course, offering advanced knowledge for practitioners and students.

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What We Talk About

• Joanne’s early exposure to MTHFR and mold illness and how it shaped her clinical work with histamine and methylation.
• What histamine actually is, what it does in the body, and why it becomes a problem when you can’t break it down.
• Common symptoms of histamine intolerance from acne, insomnia, and bloating to estrogen dominance and anxiety.
• The true root causes of histamine overload: SIBO, oxalates, mold, poor digestion, low stomach acid, and more.
• Why green juices, almond milk, and quinoa can increase oxalate load and silently drive chronic inflammation.
• How mold and mycotoxins trigger MCAS, estrogen imbalance, and methylation dysfunction, especially in women.
• What the MTHFR gene actually does, and why most people don’t need methylated B vitamins.
• The dangers of over-methylation, how to test it at home, and why women are especially susceptible.
• How vitamin C, niacinamide, and lifestyle changes can safely rebalance methylation and calm the nervous system.
• A breakdown of the key genetic SNPs involved in methylation and why gene reports are not a roadmap to supplementing.
• Joanne’s practitioner training and patient programs that help uncover the real drivers of high histamine and chronic illness.


Episode Resources

At Home Methylation Test
https://joannekennedynaturopathy.com/methylation-test/

Sequencing
Genetic testing to uncover SNPs affecting detox, methylation, and neurotransmitters.
https://shop.thetrailtohealth.com/Sequencing

Function Health
Lab testing for 100+ biomarkers including nutrients, hormones, and inflammation. Use code ESCHLICK10 for a discount.
https://shop.thetrailtohealth.com/FunctionHealth

Thorne
Clinician-trusted supplements with clean ingredients and high absorption, including B vitamins and liver support.
https://shop.thetrailtohealth.com/Thorne

BodyBio
Targeted phospholipids, butyrate, and minerals for gut, methylation, and nervous system support. Use code TRAILTOHEALTH for 15% off.
https://shop.thetrailtohealth.com/BodyBio

Pulsetto
Wearable vagus nerve stimulator to calm the nervous system and support histamine-sensitive individuals.
https://shop.thetrailtohealth.com/Pulsetto

HigherDOSE
Infrared blankets, PEMF mats, and red light tools to support detox, mitochondria, and lymph flow.
https://shop.thetrailtohealth.com/HigherDOSE

Immunolytics
At-home mold tests to detect triggers behind histamine issues and methylation stress.
https://shop.thetrailtohealth.com/Immunolytics

Jaspr
Medical-grade air purifiers to reduce mold, VOCs, and allergens. Use code TRAILTOHEALTH for 10% off.
https://shop.thetrailtohealth.com/Jaspr



Keywords

histamine intolerance, methylation, MTHFR, chronic inflammation, gut health, symptoms, root causes, genetics, health podcast, naturopathic medicine, methylation, health, genetics, hormones, nutrition, mental health, histamine, supplements, testing, naturopathy