Episode 91 - Dr. Tania Dempsey - How GLP-1s Are Transforming MCAS Treatment
/Listen To The Episode
Meet Dr. Tania Dempsey
Dr. Tania Dempsey is a leading expert in Mast Cell Activation Syndrome (MCAS) and complex chronic illness. A board-certified integrative physician, she focuses on uncovering biochemical, immune, and environmental drivers of disease. She is the founder of the AIM Center for Personalized Medicine in New York and works with patients worldwide.
What We Talk About
Dr. Tania's journey from conventional internal medicine to becoming a leading expert in mast cell activation syndrome and complex chronic illness.
Why MCAS has become increasingly common, the role of genetics, infections, toxins, and epigenetics, and how long COVID is reshaping our understanding of mast cell disorders.
The interconnected nature of chronic symptoms and why treating patients in seven minute visits never works for complex illness.
How GLP 1 receptor agonists are emerging as powerful tools for stabilizing mast cells, reducing inflammation, and improving symptoms far beyond weight loss.
Findings from her case series showing significant MCAS symptom improvement even at microdoses of semaglutide and tirzepatide.
How GLP 1s compare to traditional MCAS treatments like antihistamines, cromolyn, and leukotriene inhibitors, and why they may need to be used earlier in care.
The metabolic connection: how mast cells influence insulin resistance, why diet matters, and how approaches like carnivore or low plant toxin diets can calm mast cell activity.
The role of the nervous system, limbic retraining, and stress in driving MCAS and why nervous system work is often the first step in stabilization.
Personalized treatment: how she chooses between semaglutide, tirzepatide, and other emerging medications, and why dosing must be individualized.
Long term use, expectations, and why GLP 1s may become recognized as immune modulators rather than just metabolic therapies.
Episode Resources
Replay Dr Dempsey's latest MCAS & GLP1 Masterclass
https://drtaniadempsey.com/mcas-inflammation-glp-1-replay/
Ellie Md
High quality GLP1 and Peptide resource that offers micro dosing of GLP1
https://elliemd.com/Thetrailtohealth
Immunolytics
At home mold testing kits designed to help identify environmental triggers that can worsen MCAS and chronic inflammation.
https://shop.thetrailtohealth.com/immunolytics
AirDoctor
High efficiency air purifiers made to remove allergens, pollutants and mold spores, supporting cleaner air for sensitive immune systems.
https://shop.thetrailtohealth.com/AirDoctor
Wonderfeel
Science backed longevity formulas that support healthy aging, cellular energy and inflammation balance.
https://shop.thetrailtohealth.com/wonderfeel
Tick MiTT
Chemical free tick removal mitt designed to help safely reduce the risk of tick borne infections. Use code TRAILTOHEALTH for 10% OFF.
https://shop.thetrailtohealth.com/tickmitt
Earthing
Grounding tools that reduce environmental stress and support the autonomic nervous system.
https://shop.thetrailtohealth.com/earthing
Connect With Dr. Tania Dempsey
Instagram:
https://www.instagram.com/drtaniadempseymd/
Facebook:
https://www.facebook.com/taniadempseymd/
Keywords
MCAS, GLP 1 therapy, chronic inflammation, insulin resistance, immune dysregulation, long COVID, histamine intolerance, mold toxicity, environmental triggers, neuroinflammation, nervous system regulation, limbic system, mast cell stabilizers, personalized medicine.











