Episode 92 - Dr. Todd Maderis - Understanding SOT: Gene Silencing for Infections
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Meet Dr. Dr. Todd Maderis
Dr. Todd Maderis is the Founder and Medical Director of Marin Natural Medicine Clinic in the San Francisco Bay Area. He specializes in complex chronic illness, Lyme disease, and chronic infections. His approach focuses on identifying root causes, including infections and toxins, to create personalized treatment strategies. With over a decade of experience, Dr. Todd emphasizes precision testing and individualized care.
What We Talk About
Dr. Todd’s approach to complex chronic illness and why infections and toxins are often at the root of persistent symptoms.
What SOT (Supportive Oligonucleotide Therapy) is and how it works as a gene silencing therapy.
How SOT targets Lyme, Bartonella, Babesia, and chronic viruses like Epstein Barr, CMV, and HHV 6.
Why accurate testing is essential and how SOT is custom made from a patient’s blood.
What treatment looks like, including IV administration, timelines, and what patients typically experience.
How SOT differs from antibiotics and herbal antimicrobials, including gut impact and herx reactions.
The role of mast cell activation in chronic infections and how lowering infectious burden can calm immune overactivation.
The link between infections, mold, heavy metals, mitochondrial dysfunction, and chronic fatigue.
How long COVID can unmask underlying infections.
How infections are prioritized and sequenced in personalized treatment plans.
Real patient outcomes and who is a good candidate for SOT.
Episode Resources
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Wonderfeel
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Function Health
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Pulsetto
Vagus nerve stimulation device designed to support nervous system regulation and stress resilience.
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Connect With Dr. Todd Maderis
Instagram:
https://www.instagram.com/drtoddmaderis/
Facebook:
https://www.facebook.com/drtoddmaderis/
Website:
https://drtoddmaderis.com/
Youtube:
www.youtube.com/@tmndlac
Keywords
SOT therapy, chronic infections, Lyme disease, tick borne illness, chronic viral infections, Epstein Barr virus, immune dysregulation, mast cell activation, mold illness, environmental toxicity, mitochondrial dysfunction, chronic fatigue, long COVID, personalized medicine











